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Description of the platformIn the last decade it has become clear that the underlying disease pathologies of Alzheimer's disease (AD) and Parkinson's disease (PD) start to accumulate several decades before onset of overt symptoms. We can now use biomarkers to reliably detect these disease pathologies (e.g., amyloid-beta, tau and alpha-synuclein) even during pre-symptomatic and prodromal phases of
Special interest groups (SIGs) are groups of scientists encompassing all academic levels, from PhD students to Professors, who meet regularly to create opportunities for in-depth scientific discussion and collaborations. The SIGs are self-organizing and self-managing groups. Genetics Andreas Puschmann Fluid biomarkers Sebastian Palmqvist Cellular reprogramming Henrik Ahlenius Brain circuit analysi
https://www.multipark.lu.se/research/special-interest-groups-0 - 2025-11-19
The Brain Circuit Analysis Special Interest Group studies neuronal circuits in health and disease using advanced methods for the perturbation and recording of cell activity. In alignment with MultiPark's strategic goals Elucidate disease mechanisms at molecular, cellular and circuitry levels, guiding the development of new therapies, such as restoration of lost brain functions based on cell- and
https://www.multipark.lu.se/brain-circuit-analysis - 2025-11-19
This group brings together researchers who look for causes of neurodegenerative diseases in the genetic code of our patient series and families. DNA from an increasing number of patients is being examined by whole genome or whole exome sequencing methods, and group members are involved in the genetic analyses of this genetic data. Members represent those who primarily look for monogenic disease ca
https://www.multipark.lu.se/genetics-neurodegenerative-diseases - 2025-11-19
The Molecular Signaling Special Interest Group focus on genetics and their effects on different neurodegenerative disorders. Everything from gene expression, gene therapy, and epigenetic mechanisms is considered. This SIG combines a broad range of research topics. These include genetics, gene expression, gene therapy, and epigenetic mechanisms and their associated effects on different neurodegener
https://www.multipark.lu.se/molecular-signaling-neurodegenerative-diseases - 2025-11-19
The MESO QuickPlex SQ 120 is a multiplexing plate reader using high-performance, electrochemiluminescence (ECL) immunoassays for detecting biomarkers. The instrument allows for precise quantitation of single or multiple, low to elevated abundance analytes, in a single sample. The MULTI-ARRAY technology has increased dynamic range, improved sensitivity, reduced sample volume and reagent requirement
https://www.multipark.lu.se/infrastructures/meso-quickplex - 2025-11-19
MultiPark supports up to 50% of a clinical bioinformatician, for projects within the aims of MultiPark.The bioinformatician works with bioinformatic analyses of genetic data from high throughput genetic sequencing from patients and families with Parkinson disease, dementia, other movement disorders and cerebrovascular disorders. Tasks/expertise include the identification of disease-associated gene
https://www.multipark.lu.se/infrastructures/clinical-bioinformatics-infrastructure - 2025-11-19
MultiPark NGS database is completed and available to interested MultiPark researchers. Data from whole exome sequencing of 287 clinically well-characterized Parkinson disease patients from southern Sweden is now available in the MultiPark NGS database. Patients had been recruited within the PARkinsonLUnd (PARLU) study and MultiPark’s biobank sample collection(MPBC). Great care has been taken to en
https://www.multipark.lu.se/infrastructures/ngs-database-infrastructure - 2025-11-19
High-content analysis system High content screening (HCS) / Analysis (HCA) enables automated acquisition, visualization and quantification of a large number of images and can capture and measure dynamic processes, such as migration and/or changes in morphology, expression pattern and/or intensity.This system featuresAutomated fluorescence and brightfield microscopyWidefield and confocal (spinning
https://www.multipark.lu.se/infrastructures/operetta-cls - 2025-11-19
According to a decision made by the MultiPark board, the infrastructures have been evaluated. Kajsa Paulsson, one of the external board members, has been responsible for this process. Read the general conclusions of the evaluation report from November 2022 here: Evaluation of the MultiPark Research Infrastructures Nov 2022.pdf
https://www.multipark.lu.se/infrastructures/infrastructure-evaluation - 2025-11-19
Read about our latest scientific discoveries See all publications from our research groups here.
https://www.multipark.lu.se/research/publications - 2025-11-19
Visit MultiPark Café (link to Swedish event site) MultiPark Café MultiPark Café is a series of popular science lectures (in Swedish) where our researchers present their latest discoveries. The seminars are aimed at patient associations and the general public and each evening has a specific theme.More information about these events can be found on our Swedish homepage. Listen to Meet our scientists
https://www.multipark.lu.se/outreaching-activities-0 - 2025-11-19
As of January 2025, the sequencing services previously provided by the MultiPark Neuroscience Omics Facility (formerly known as the Next Generation Sequencing Facility) can be accessed by directly contacting the Center for Translational Genomics at Lund University (https://www.ctg.lu.se/ctg-center-translational-genomics).Some equipment funded by MultiPark for use in the former facility will still
https://www.multipark.lu.se/infrastructures/ngs-equipment - 2025-11-19
PET imaging of the brain is a powerful method to study physiology and disease in the living brain of humans as well as animal models. The unit for nuclear medicin at Skåne University Hospital provides radioligands for both experimental and clinical use. Besides 18F-FDG, they also synthesize a range of other PET tracers such as ligands binding to the dopamine transporter, tau filaments or β-amyloid
https://www.multipark.lu.se/infrastructures/pet-ligand-radiosynthesis-platform - 2025-11-19
High content screening (HCS)/Analysis (HCA) Left: photo of the Plate Runner HD from Trophos. Upper right: whole well image of culture well (96 well plate format) containing human induced pluripotent stem cells grown on mouse feeders, stained for pluripotent markers NANOG (red) and OCT4 (green). The cell nuclei is stained with DAPI (blue). Lower right: whole well image of culture well (96 well plat
https://www.multipark.lu.se/infrastructures/plate-runner-platform - 2025-11-19
Quanterix SR-X Ultra-Sensitive Biomarker Detection System The Simoa Analyzer is particularly useful for measurements of biomarkers at ultra-low levels.The Simoa Analyzer system features:Single molecule array technique for high sensitivity and broad dynamic rangeCombined digital and analog immunoassay dynamic range is >4 logsA range of sample types include serum, plasma, cerebrospinal fluid, urine,
https://www.multipark.lu.se/infrastructures/simoa-analyzer - 2025-11-19
MultiPark's podcast series In this podcast series, young MultiPark researchers interview our research group leaders about their academic journey and main scientific focus. Emma Nyberg and Lluís Camprubí Ferrer, the Young MultiPark working group members, carry out the interviews. Listen to the introduction episode of our podcast series here: E0_MultiPark's podcast series Meet Our Scientists Mul
https://www.multipark.lu.se/meet-our-scientists - 2025-11-19
Planning Introduction to Simoa: all users that require assistance with how to operate the microplate washer, shaker and SR-X reader, please contact XXX For assistance in assay choice or development, contact Quanterix. For overview of assay kits and custom-developed assays, go to links below: Quanterix Simoa Assay Kits Quanterix Simoa Homebrew custom assay development Register on the Quanterix cus
https://www.multipark.lu.se/services-simoa - 2025-11-19
Young MultiParker's image competition of 2023 We're excited to announce our upcoming "Brain in Picture" photo contest! The theme of the competition: The challenge is to capture the essence of brain research in a single snapshot. We're looking for images that showcase neuroscience's beauty, complexity, and wonder (It could be immune staining of brain cells, MRI, PET, or other things linked to your
https://www.multipark.lu.se/brain-picture - 2025-11-19
The Neuroscience graduate school seminars are held twice a month on Wednesdays at 12:00-13:00 in room I1345, BMC I13. This is your chance to hear about the research happening in the MultiPark research environment, as well as to socialize after the presentations. Seminars autumn 202517 SeptemberYu XiaoChandramouli MuralidharanOsama Elabi 1 OctoberAmanda AnnettesdotterYiyi YangJosef Getachew 15 Octo
